Additive effects of 10-year exposures to PM_2.5 and NO₂ and primary cancer incidence in American older adults.

ABSTRACT: Epidemiologic evidence on the relationships between air pollution and the risks of primary cancers other than lung cancer remained largely lacking. We aimed to examine associations of 10-year exposures to fine particulate matter (PM_2.5) and nitrogen dioxide (NO₂) with risks of breast, prostate, colorectal, and endometrial cancers.

Methods

For each cancer, we constructed a separate cohort among the national Medicare beneficiaries during 2000 to 2016. We simultaneously examined the additive associations of six exposures, namely, moving average exposures to PM_2.5 and NO₂ over the year of diagnosis and previous 2 years, previous 3 to 5 years, and previous 6 to 10 years, with the risk of first cancer diagnosis after 10 years of follow-up, durin

SUBMITTER: Wei Y 

PROVIDER: S-EPMC10402937 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature