Avoiding scar tissue formation of peripheral nerves with the help of an acellular collagen matrix.

ABSTRACT:

Introduction

Extensive scar tissue formation after peripheral nerve injury or surgery is a common problem. To avoid perineural scarring, implanting a mechanical barrier protecting the nerve from inflammation processes in the perineural environment has shown promising results for functional recovery. This study investigates the potential of an acellular collagen-elastin matrix wrapped around a peripheral nerve after induction of scar tissue formation.

Materials and methods

In the present study, 30 Lewis rats were separated into three groups and sciatic nerve scarring was induced with 2.5% glutaraldehyde (GA-CM) or 2.5% glutaraldehyde with a supplemental FDA-approved acellular collagen-elastin matrix application (GA+CM). Additionally, a sham group was included for control. Ner

SUBMITTER: Aman M 

PROVIDER: S-EPMC10403074 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature