Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection.

ABSTRACT:

Background

Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndromes (ACS) afflicting predominantly younger to middle-aged women. Observational studies have reported a high prevalence of extracoronary vascular anomalies, especially fibromuscular dysplasia (FMD) and a low prevalence of coincidental cases of atherosclerosis. PHACTR1/EDN1 is a genetic risk locus for several vascular diseases, including FMD and coronary artery disease, with the putative causal noncoding variant at the rs9349379 locus acting as a potential enhancer for the endothelin-1 (EDN1) gene.

Objectives

This study sought to test the association between the rs9349379 genotype and SCAD.

Methods

Results from case control studies from France, United Kin

SUBMITTER: Adlam D 

PROVIDER: S-EPMC10403154 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature