Motor-driven advection competes with crowding to drive spatiotemporally heterogeneous transport in cytoskeleton composites.

ABSTRACT: The cytoskeleton-a composite network of biopolymers, molecular motors, and associated binding proteins-is a paradigmatic example of active matter. Particle transport through the cytoskeleton can range from anomalous and heterogeneous subdiffusion to superdiffusion and advection. Yet, recapitulating and understanding these properties-ubiquitous to the cytoskeleton and other out-of-equilibrium soft matter systems-remains challenging. Here, we combine light sheet microscopy with differential dynamic microscopy and single-particle tracking to elucidate anomalous and advective transport in actomyosin-microtubule composites. We show that particles exhibit multi-mode transport that transitions from pronounced subdiffusion to superdiffusion at tunable crossover timescales. Surprisingly, while high

SUBMITTER: Sheung JY 

PROVIDER: S-EPMC10403238 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature