Brain Structure Relations With Psychopathology Trajectories in the ABCD Study.

ABSTRACT:

Objective

A general psychopathology (p) factor captures shared variation across mental disorders. Structural neural alterations have been associated with the p factor concurrently, but less is known about whether these alterations relate to within-person change in the p factor over time, especially during preadolescence, a period of neurodevelopmental changes.

Method

This study examined whether baseline brain structure was prospectively related to the trajectory of the p factor and specific forms of psychopathology over 2 years in 9,220 preadolescents (aged 9-10 at baseline) from the Adolescent Brain Cognitive Development Study (ABCD). Longitudinal multilevel models were conducted to determine whether baseline brain structure (volume, surface area, thickness) was associated

SUBMITTER: Romer AL 

PROVIDER: S-EPMC10403371 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature