Premature infants born <28 weeks with acute kidney injury have increased bronchopulmonary dysplasia rates.

ABSTRACT:

Background

Despite a growing understanding of bronchopulmonary dysplasia (BPD) and advances in management, BPD rates remain stable. There is mounting evidence that BPD may be due to a systemic insult, such as acute kidney injury (AKI). Our hypothesis was that severe AKI would be associated with BPD.

Methods

We conducted a secondary analysis of premature infants [24-27 weeks gestation] in the Recombinant Erythropoietin for Protection of Infant Renal Disease cohort (N = 885). We evaluated the composite outcome of Grade 2/3 BPD or death using generalized estimating equations. In an exploratory analysis, urinary biomarkers of angiogenesis (ANG1, ANG2, EPO, PIGF, TIE2, FGF, and VEGFA/D) were analyzed.

Results

594 (67.1%) of infants had the primary composite outcome of Grad

SUBMITTER: Starr MC 

PROVIDER: S-EPMC10403374 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature