Single-cell Hi-C data enhancement with deep residual and generative adversarial networks.

ABSTRACT:

Motivation

The spatial genome organization of a eukaryotic cell is important for its function. The development of single-cell technologies for probing the 3D genome conformation, especially single-cell chromosome conformation capture techniques, has enabled us to understand genome function better than before. However, due to extreme sparsity and high noise associated with single-cell Hi-C data, it is still difficult to study genome structure and function using the HiC-data of one single cell.

Results

In this work, we developed a deep learning method ScHiCEDRN based on deep residual networks and generative adversarial networks for the imputation and enhancement of Hi-C data of a single cell. In terms of both image evaluation and Hi-C reproducibility metrics, ScHiCEDRN outperf

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10403428 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature