Glucose-dependent inflammatory responses in obese compared to lean individuals.

ABSTRACT:

Purpose

Obesity is characterized by chronic inflammation that may contribute to insulin resistance and promote type 2 diabetes. We have investigated whether inflammatory responses to glycemic and insulinemic variations are altered in obese individuals.

Methods

Eight obese and eight lean individuals without diabetes had undergone hyperinsulinemic-euglycemic-hypoglycemic and hyperglycemic clamps in a previous study. Using Proximity Extension Assay, 92 inflammatory markers were analyzed from plasma samples at fasting, hyperinsulinemia-euglycemia, hypoglycemia and hyperglycemia.

Results

In all participants, hyperinsulinemia, hypoglycemia and hyperglycemia led to reductions of 11, 19 and 62 out of the 70 fully evaluable biomarkers, respectively. FGF-21 increased during bot

SUBMITTER: Lundqvist MH 

PROVIDER: S-EPMC10403442 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature