Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair.

ABSTRACT: Biological rhythms are involved in almost all types of biological processes, not only physiological processes but also morphogenesis. Currently, how periodic morphological patterns of tissues/organs in multicellular organisms form is not fully understood. Here, using mouse zigzag hair, which has 3 bends, we found that a change in the combination of hair progenitors and their micro-niche and subsequent bend formation occur every three days. Chimeric loss-of-function and gain-of-function of Ptn and Aff3, which are upregulated immediately before bend formation, resulted in defects in the downward movement of the micro-niche and the rhythm of bend formation in an in vivo hair reconstitution assay. Our study demonstrates the periodic change in the combination between progenitors and micro-niche

SUBMITTER: Takeo M 

PROVIDER: S-EPMC10403492 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature