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Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair.

ABSTRACT: Biological rhythms are involved in almost all types of biological processes, not only physiological processes but also morphogenesis. Currently, how periodic morphological patterns of tissues/organs in multicellular organisms form is not fully understood. Here, using mouse zigzag hair, which has 3 bends, we found that a change in the combination of hair progenitors and their micro-niche and subsequent bend formation occur every three days. Chimeric loss-of-function and gain-of-function of Ptn and Aff3, which are upregulated immediately before bend formation, resulted in defects in the downward movement of the micro-niche and the rhythm of bend formation in an in vivo hair reconstitution assay. Our study demonstrates the periodic change in the combination between progenitors and micro-niche, which is vital for the unique infradian rhythm.

SUBMITTER: Takeo M

PROVIDER: S-EPMC10403492 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair.

Takeo Makoto M Toyoshima Koh-Ei KE Fujimoto Riho R Iga Tomoyo T Takase Miki M Ogawa Miho M Tsuji Takashi T

Nature communications 20230804 1

Biological rhythms are involved in almost all types of biological processes, not only physiological processes but also morphogenesis. Currently, how periodic morphological patterns of tissues/organs in multicellular organisms form is not fully understood. Here, using mouse zigzag hair, which has 3 bends, we found that a change in the combination of hair progenitors and their micro-niche and subsequent bend formation occur every three days. Chimeric loss-of-function and gain-of-function of Ptn an ...[more]

PMID: 37542032

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