Membrane mediated mechanical stimuli produces distinct active-like states in the AT1 receptor.

ABSTRACT: The Angiotensin II Type 1 (AT1) receptor is one of the most widely studied GPCRs within the context of biased signaling. While the AT1 receptor is activated by agonists such as the peptide AngII, it can also be activated by mechanical stimuli such as membrane stretch or shear in the absence of a ligand. Despite the importance of mechanical activation of the AT1 receptor in biological processes such as vasoconstriction, little is known about the structural changes induced by external physical stimuli mediated by the surrounding lipid membrane. Here, we present a systematic simulation study that characterizes the activation of the AT1 receptor under various membrane environments and mechanical stimuli. We show that stability of the active state is highly sensitive to membrane thickness and t

SUBMITTER: Poudel B 

PROVIDER: S-EPMC10403497 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature