Metagenomic surveillance uncovers diverse and novel viral taxa in febrile patients from Nigeria.

ABSTRACT: Effective infectious disease surveillance in high-risk regions is critical for clinical care and pandemic preemption; however, few clinical diagnostics are available for the wide range of potential human pathogens. Here, we conduct unbiased metagenomic sequencing of 593 samples from febrile Nigerian patients collected in three settings: i) population-level surveillance of individuals presenting with symptoms consistent with Lassa Fever (LF); ii) real-time investigations of outbreaks with suspected infectious etiologies; and iii) undiagnosed clinically challenging cases. We identify 13 distinct viruses, including the second and third documented cases of human blood-associated dicistrovirus, and a highly divergent, unclassified dicistrovirus that we name human blood-associated dicistrovirus

SUBMITTER: Oguzie JU 

PROVIDER: S-EPMC10403498 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature