A microfluidic platform for the controlled synthesis of architecturally complex liquid crystalline nanoparticles.

ABSTRACT: Soft-matter nanoparticles are of great interest for their applications in biotechnology, therapeutic delivery, and in vivo imaging. Underpinning this is their biocompatibility, potential for selective targeting, attractive pharmacokinetic properties, and amenability to downstream functionalisation. Morphological diversity inherent to soft-matter particles can give rise to enhanced functionality. However, this diversity remains untapped in clinical and industrial settings, and only the simplest of particle architectures [spherical lipid vesicles and lipid/polymer nanoparticles (LNPs)] have been routinely exploited. This is partially due to a lack of appropriate methods for their synthesis. To address this, we have designed a scalable microfluidic hydrodynamic focusing (MHF) technology for t

SUBMITTER: Pilkington CP 

PROVIDER: S-EPMC10403506 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature