A multi-omics analysis identifies molecular features associated with fertility in heifers (Bos taurus).

ABSTRACT: Infertility or subfertility is a critical barrier to sustainable cattle production, including in heifers. The development of heifers that do not produce a calf within an optimum window of time is a critical factor for the profitability and sustainability of the cattle industry. In parallel, heifers are an excellent biomedical model for understanding the underlying etiology of infertility because well-nourished heifers can still be infertile, mostly because of inherent physiological and genetic causes. Using a high-density single nucleotide polymorphism (SNP) chip, we collected genotypic data, which were analyzed using an association analysis in PLINK with Fisher's exact test. We also produced quantitative transcriptome data and proteome data. Transcriptome data were analyzed using the quas

SUBMITTER: Marrella MA 

PROVIDER: S-EPMC10403585 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature