Impaired cecal motility and secretion alongside expansion of gut-associated lymphoid tissue in the Nlgn3^R451C mouse model of autism.

ABSTRACT: Individuals with Autism Spectrum Disorder (ASD; autism) commonly present with gastrointestinal (GI) illness in addition to core diagnostic behavioural traits. The appendix, or cecum in mice, is important for GI homeostasis via its function as a key site for fermentation and a microbial reservoir. Even so, the role of the appendix and cecum in autism-associated GI symptoms remains uninvestigated. Here, we studied mice with an autism-associated missense mutation in the post-synaptic protein neuroligin-3 (Nlgn3^R451C), which impacts brain and enteric neuronal activity. We assessed for changes in cecal motility using a tri-cannulation video-imaging approach in ex vivo preparations from wild-type and Nlgn3^R451C mice. We investigated cecal permeability and neurally-evoked se

SUBMITTER: Lee CYQ 

PROVIDER: S-EPMC10403596 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature