Spatio-temporal activation patterns of neuronal population evoked by optostimulation and the comparison to electrical microstimulation.

ABSTRACT: Optostimulation and electrical microstimulation are well-established techniques that enable to artificially stimulate the brain. While the activation patterns evoked by microstimulation in cortical network are well characterized, much less is known for optostimulation. Specifically, the activation maps of neuronal population at the membrane potential level and direct measurements of these maps were barely reported. In addition, only a few studies compared the activation patterns evoked by microstimulation and optostimulation. In this study we addressed these issues by applying optostimulation in the barrel cortex of anesthetized rats after a short (Short_Exp) or a long (Long_Exp) opsin expression time and compared it to microstimulation. We measured the membrane potenti

SUBMITTER: Margalit SN 

PROVIDER: S-EPMC10403613 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature