Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis.

ABSTRACT: In the adult mammalian brain, neural stem cells (NSCs) located in highly restricted niches sustain the generation of new neurons that integrate into existing circuits. A reduction in adult neurogenesis is linked to ageing and neurodegeneration, whereas dysregulation of proliferation and survival of NSCs have been hypothesized to be at the origin of glioma. Thus, unravelling the molecular underpinnings of the regulated activation that NSCs must undergo to proliferate and generate new progeny is of considerable relevance. Current research has identified cues promoting or restraining NSCs activation. Yet, whether NSCs depend on external signals to survive or if intrinsic factors establish a threshold for sustaining their viability remains elusive, even if this knowledge could involve potentia

SUBMITTER: Del Puerto A 

PROVIDER: S-EPMC10403621 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature