Alveolar Dead Space Is Augmented During Exercise in Patients With Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Patients with heart failure with preserved ejection fraction (HFpEF) exhibit many cardiopulmonary abnormalities that could result in V˙/Q˙ mismatch, manifesting as an increase in alveolar dead space (VD_alveolar) during exercise. Therefore, we tested the hypothesis that VD_alveolar would increase during exercise to a greater extent in patients with HFpEF compared with control participants.

Research question

Do patients with HFpEF develop VD_alveolar during exercise?

Study design and methods

Twenty-three patients with HFpEF and 12 control participants were studied. Gas exchange (ventilation [V˙_E], oxygen uptake [V˙o₂], and CO₂ elimination [V˙co₂]) and arterial blood gases were analyzed

SUBMITTER: Balmain BN 

PROVIDER: S-EPMC10403624 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature