SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis.

ABSTRACT:

Introduction

Serum amyloid P component (SAP) regulates the innate immune system and microbial diseases. Periodontitis is an inflammatory oral disease developed by the host immune system's interaction with the dysbiotic oral microbiome, thereby SAP could play a role in periodontitis pathogenicity.

Objectives

To investigate the role of SAP in oral microbiome modulation and peridontitis pathogenicity.

Methods

In this study, wildtype and SAP-knockout (KO) mice were used. Ligature-based periodontitis was developed in mice. Oral microbiome diversity was analyzed by 16 s rRNA sequencing. Macrophages and Porphyromonas gingivalis (P. gingivalis) co-culture system analyzed the effect of SAP in macrophage phagocytosis of P. gingivalis.

Results

The level of SAP was upregul

SUBMITTER: Wang L 

PROVIDER: S-EPMC10403661 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature