Common Risk Variants in <i>AHI1</i> Are Associated With Childhood Steroid Sensitive Nephrotic Syndrome.

ABSTRACT:

Introduction

Steroid-sensitive nephrotic syndrome (SSNS) is the most common form of kidney disease in children worldwide. Genome-wide association studies (GWAS) have demonstrated the association of SSNS with genetic variation at HLA-DQ/DR and have identified several non-HLA loci that aid in further understanding of disease pathophysiology. We sought to identify additional genetic loci associated with SSNS in children of Sri Lankan and European ancestry.

Methods

We conducted a GWAS in a cohort of Sri Lankan individuals comprising 420 pediatric patients with SSNS and 2339 genetic ancestry matched controls obtained from the UK Biobank. We then performed a transethnic meta-analysis with a previously reported European cohort of 422 pediatric patients and 5642 contro

SUBMITTER: Downie ML 

PROVIDER: S-EPMC10403666 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature