Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation.

ABSTRACT:

Introduction

Myogenic differentiation plays an important role in pathophysiological processes including muscle injury and regeneration, as well as muscle atrophy. A novel type of posttranslational modification, crotonylation, has been reported to play a role in stem cell differentiation and disease. However, the role of crotonylation in myogenic differentiation has not been clarified.

Objectives

This study aims to find the role of crotonylation during myogenic differentiation and explore whether it is a potential target in myogenic dysfunction disease.

Methods

C2C12 cell line and skeletal muscle mesenchymal progenitors of Mus musculus were used for myogenic process study in vitro, while muscle injury model of mice was used for in vivo muscle regeneration study. Mass s

SUBMITTER: Qian Z 

PROVIDER: S-EPMC10403674 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature