Clinicopathologic Spectrum of Lysozyme-Associated Nephropathy.

ABSTRACT:

Introduction

Lysozyme-associated nephropathy (LyN), a rare cause of kidney injury in patients with chronic myelomonocytic leukemia (CMML), has not been well described to date. We report the clinicopathologic spectrum of LyN from a multi-institutional series.

Method

We identified 37 native kidney biopsies with LyN and retrospectively obtained clinicopathologic data.

Results

Thirty-seven patients had a median age of 74 years and included 78% males. Their most common presentation was acute kidney injury (AKI) or AKI on chronic kidney disease (CKD) (66%) with median estimated glomerular filtration rate (eGFR) of 21.7 ml/min per 1.73 m², and proteinuria of 1.7 g. A minority (15%) had partial Fanconi syndrome. Serum lysozyme levels were elevated in all tested. He

SUBMITTER: Kudose S 

PROVIDER: S-EPMC10403676 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature