Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment.

ABSTRACT:

Background

Parkinson's disease (PD) is a disease of ⍺-synuclein aggregation-mediated dopaminergic neuronal loss in the substantia nigra pars compacta, which leads to motor and non-motor symptoms. Through the last two decades of research, there has been growing consensus that inflammation-mediated oxidative stress, mitochondrial dysfunction, and cytokine-induced toxicity are mainly involved in neuronal damage and loss associated with PD. However, it remains unclear how these mechanisms relate to sporadic PD, a more common form of PD. Both enteric and central nervous systems have been implicated in the pathogenesis of sporadic PD, thus highlighting the crosstalk between the gut and brain.

Aim

of Review: In this review, we summarize how alterations in the gut microbiome can aff

SUBMITTER: Salim S 

PROVIDER: S-EPMC10403695 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature