Measures of Connectivity and Dorsolateral Prefrontal Cortex Volumes and Depressive Symptoms Following Treatment With Selective Serotonin Reuptake Inhibitors in Adolescents.

ABSTRACT:

Importance

Selective serotonin reuptake inhibitors (SSRIs) are considered a first-line pharmacological treatment for adolescent depression with moderate or higher levels of symptom severity. Thus, it is important to understand neurobiological changes related to SSRIs during the course of treatment for adolescents with depression.

Objective

To examine neurobiological changes associated with SSRI treatment in adolescents with major depressive disorder (MDD) by measuring longitudinal changes in volume and resting-state functional connectivity (rsFC) in the dorsolateral prefrontal cortex (DLPFC), a core region of cognitive control.

Design, setting, and participants

This cohort study was conducted with an open-label design. Adolescents with MDD and healthy controls were re

SUBMITTER: Lee KH 

PROVIDER: S-EPMC10403785 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature