Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants.

ABSTRACT:

Background

Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity.

Methods

EBC samples and respiratory questionnaires were collected from 15 term-born infants and 33 preterm-born infants, 12 with a neonatal BPD diagnosis. EBC samples were analysed for leukotriene B4 (inflammation) and 8-isoprostane (oxidative stress) concentrations using enzyme-linked immune-assays. Differences between

SUBMITTER: Urs R 

PROVIDER: S-EPMC10403823 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature