Causal association between gut microbiota and intrahepatic cholestasis of pregnancy: mendelian randomization study.

ABSTRACT:

Background

Previous observational cohort studies have shown that the composition of the gut microbiota is related to the risk of intrahepatic cholestasis of pregnancy (ICP), although it is unclear if the association is causative. This study used Mendelian randomization (MR) to systematically examine whether the gut microbiota was causally linked to ICP.

Methods

We obtained the genome-wide association study (GWAS) summary statistics of gut microbiota and ICP from published GWASs. Maximum likelihood (ML), MR-Egger regression, weighted median, inverse variance weighted (IVW), and weighted model were used to investigate the causal association between gut microbiota and ICP. We further conducted a series of sensitivity analyses to confirm the robustness of the primary results of

SUBMITTER: Li C 

PROVIDER: S-EPMC10403878 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature