CSF1R regulates schizophrenia-related stress response and vascular association of microglia/macrophages.

ABSTRACT:

Background

Microglia are known to regulate stress and anxiety in both humans and animal models. Psychosocial stress is the most common risk factor for the development of schizophrenia. However, how microglia/brain macrophages contribute to schizophrenia is not well established. We hypothesized that effector molecules expressed in microglia/macrophages were involved in schizophrenia via regulating stress susceptibility.

Methods

We recruited a cohort of first episode schizophrenia (FES) patients (n = 51) and age- and sex-paired healthy controls (HCs) (n = 46) with evaluated stress perception. We performed blood RNA-sequencing (RNA-seq) and brain magnetic resonance imaging, and measured plasma level of colony stimulating factor 1 receptor (CSF1R). Furthermore, we studied a mous

SUBMITTER: Yan L 

PROVIDER: S-EPMC10403881 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature