Identifying novel regulatory effects for clinically relevant genes through the study of the Greek population.

ABSTRACT:

Background

Expression quantitative trait loci (eQTL) studies provide insights into regulatory mechanisms underlying disease risk. Expanding studies of gene regulation to underexplored populations and to medically relevant tissues offers potential to reveal yet unknown regulatory variants and to better understand disease mechanisms. Here, we performed eQTL mapping in subcutaneous (S) and visceral (V) adipose tissue from 106 Greek individuals (Greek Metabolic study, GM) and compared our findings to those from the Genotype-Tissue Expression (GTEx) resource.

Results

We identified 1,930 and 1,515 eGenes in S and V respectively, over 13% of which are not observed in GTEx adipose tissue, and that do not arise due to different ancestry. We report additional context-specific regulato

SUBMITTER: Rouskas K 

PROVIDER: S-EPMC10403965 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature