The Role of Maternal Preconception Adiposity in Human Offspring Sex and Sex Ratio.

ABSTRACT: We evaluated relationships between preconception adiposity and human offspring sex and sex ratio. Using data from a prospective preconception cohort nested within a randomized controlled trial based at 4 US clinical sites (2006-2012), we used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for male:female sex ratio, and log-identity regression to estimate risk differences (RDs) and 95% CIs for male and female livebirth according to preconception adiposity measures. Inverse-probability weights accounted for potential selection bias. Among 603 women attempting pregnancy, there were meaningful reductions in sex ratio for the highest category of each adiposity measure. The lowest sex ratios were observed for obesity (body mass index of ≥30, calculated as we

SUBMITTER: DeVilbiss EA 

PROVIDER: S-EPMC10404066 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature