Endogenous Steroid Hormone Concentrations and Risk of Endometriosis in Nurses' Health Study II.

ABSTRACT: Few studies have assessed the association between endogenous steroid hormone levels and a subsequent diagnosis of endometriosis. We prospectively evaluated premenopausal plasma sex hormone levels and the risk of laparoscopically confirmed endometriosis in a nested case-control study within Nurses' Health Study II. Between blood collection (1996-1999) and 2009, we ascertained 446 women with incident endometriosis and matched them to 878 controls through risk-set sampling. We conducted multivariable conditional logistic regression accounting for matching and confounders to estimate relative risks (RRs) and 95% confidence intervals (CIs). Women with greater early follicular-phase total or free estradiol levels had a nonlinear increased risk of endometriosis (early follicular total estradiol:

SUBMITTER: Shafrir AL 

PROVIDER: S-EPMC10404067 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature