An integrated analysis of microRNAs regulating DNA damage response in triple-negative breast cancer.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) remains a clinical challenge due to its aggressive phenotype and limited treatment options for the patients. Many TNBC patients show an inherent defect in the DNA repair capacity primarily by acquiring germline mutations in BRCA1 and BRCA2 genes leading to Homologous Recombination Deficiency (HRD). Epigenetic modifications such as BRCA1 promoter methylation and miRNA expression targeting DNA repair pathway genes have contributed to the HRD phenotype in TNBC. Hence, we aimed to identify microRNAs that are associated with HRD status in the TCGA-BRCA project.

Materials and methods

We implemented a miRNA prediction strategy for identifying miRNAs targeting HR pathway genes using an in silico predicted and experimentally validated l

SUBMITTER: Kuthethur R 

PROVIDER: S-EPMC10404216 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature