Construction and validation of a prognostic model for colon adenocarcinoma based on bile acid metabolism-related genes.

ABSTRACT: Colon adenocarcinoma (COAD), one of the common clinical cancers, exhibits high morbidity and mortality, and its pathogenesis and treatment are still underdeveloped. Numerous studies have demonstrated the involvement of bile acids in tumour development, while the potential role of their metabolism in the tumor microenvironment (TME) has not been explored. A collection of 481 genes related to bile acid metabolism were obtained, and The Cancer Genome Atlas-based COAD risk model was developed using the least absolute shrinkage selection operator (LASSO) regression analysis. The Gene Expression Omnibus dataset was used to validate the results. The predictive performance of the model was verified using column line plots, principal component analysis and receiver operating characteristic curves.

SUBMITTER: Luo Q 

PROVIDER: S-EPMC10404223 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature