Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia.

ABSTRACT: Defects in essential metabolic regulation for energy supply, increased oxidative stress promoting excitatory/inhibitory imbalance and phospholipid membrane dysfunction have been implicated in the pathophysiology of schizophrenia (SZ). The knowledge about the developmental trajectory of these key pathophysiological components and their interplay is important to develop new preventive and treatment strategies. However, this assertion is so far limited. To investigate the developmental regulations of these key components in the brain, we assessed, for the first time, in vivo redox state from the oxidized (NAD⁺) and reduced (NADH) form of Nicotinamide Adenine Dinucleotide (NAD), energy and membrane metabolites, inhibitory and excitatory neurotransmitters by ³¹P and ¹

SUBMITTER: Skupienski R 

PROVIDER: S-EPMC10404265 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature