Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study.

ABSTRACT: Sleep disordered breathing (SDB), mainly obstructive sleep apnea (OSA), constitutes a major health problem due to the large number of patients. Intermittent hypoxia caused by SDB induces alterations in metabolic function. Nevertheless, metabolites characteristic for SDB are largely unknown. In this study, we performed gas chromatography-mass spectrometry-based targeted metabolome analysis using data from The Nagahama Study (n = 6373). SDB-related metabolites were defined based on their variable importance score in orthogonal partial least squares discriminant analysis and fold changes in normalized peak-intensity levels between moderate-severe SDB patients and participants without SDB. We identified 20 metabolites as SDB-related, and interestingly, these metabolites were frequently include

SUBMITTER: Nakatsuka Y 

PROVIDER: S-EPMC10404271 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature