Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments.

ABSTRACT: Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H₂O₂ → ‧OH for tumoral therapy. Unfortunately, H₂O₂ is often taken from the limited endogenous supply of H₂O₂ in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H₂O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe³⁺-N ≡ C-Fe²⁺ composition through the proposed proton-induced metal replacement reactions. Surprisingly, both the CFPB nanocub

SUBMITTER: Wang LC 

PROVIDER: S-EPMC10404294 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature