Polymorphism of LRP4 Gene (rs9667108) among Post Menopause Women with Osteoporosis.

ABSTRACT:

Background

Many studies have been done to identify the factors that influence the development and progression of osteoporosis. One genetic factor is polymorphisms of LRP4 gene. Regarding the lack of comprehensive study on polymorphisms of LRP4 gene in the north of Iran, mainly Mazandaran Province, we decided to investigate the polymorphism of this gene in postmenopausal women with osteoporosis.

Methods

This case-control study has been conducted at GhaemShahr Valiasr Hospital on 100 female patients with osteoporosis (average age of 58.1) and 90 healthy females without osteoporosis (average age of 55.2). After sampling and extraction of genomic DNA via of the salt deposition method, the genotype and SNP (rs9667108) polymorphism of LRP4 gene were evaluated

SUBMITTER: Kavoosian S 

PROVIDER: S-EPMC10404332 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature