Oleuropein as An Effective Suppressor of Inflammation and MicroRNA-146a Expression in Patients with Rheumatoid Arthritis.

ABSTRACT:

Objective

Rheumatoid arthritis (RA) is a common progressive autoimmune disorder that causes chronic inflammation of the joints and damage to other organs. Previous studies have reported the important role of miRNA-146a in the pathogenesis of RA. In addition, the anti-inflammatory and modulatory effects of oleuropein (OLEU) on the expression pattern of microRNAs (miRNAs) have been shown in different diseases. Therefore, this study aimed to evaluate both the sensitivity and specificity of miRNA-146a and determine the potential effects of OLEU on the expression levels of miRNA-146a and tumour necrosis factor-alpha (TNF-α) in RA patients.

Materials and methods

The participants in this experimental study were divided into 2 groups: RA (n=45) and healthy controls (n=30). The isola

SUBMITTER: Mahi H 

PROVIDER: S-EPMC10404353 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature