Mistranslation of the genetic code by a new family of bacterial transfer RNAs.

ABSTRACT: The correct coupling of amino acids with transfer RNAs (tRNAs) is vital for translating genetic information into functional proteins. Errors during this process lead to mistranslation, where a codon is translated using the wrong amino acid. While unregulated and prolonged mistranslation is often toxic, growing evidence suggests that organisms, from bacteria to humans, can induce and use mistranslation as a mechanism to overcome unfavorable environmental conditions. Most known cases of mistranslation are caused by translation factors with poor substrate specificity or when substrate discrimination is sensitive to molecular changes such as mutations or posttranslational modifications. Here we report two novel families of tRNAs, encoded by bacteria from the Streptomyces and Kitasatospora gene

SUBMITTER: Schuntermann DB 

PROVIDER: S-EPMC10404621 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature