Gut microbiota and their metabolite profiles following peripheral nerve xenotransplantation.

ABSTRACT:

Background

Intestinal pathogens are associated with xenotransplantation tolerance and rejection. However, changes in the gut microbiota in patients who have undergone peripheral nerve xenotransplantation and their association with immune rejection have not yet been reported.

Objective

We aimed to explore intestinal microbes and their metabolites at different time points after peripheral nerve transplantation to provide new insight into improving transplant tolerance.

Methods

A peripheral nerve xenotransplantation model was constructed by suturing the segmented nerves of Sprague Dawley rats to those of C57 male mice using xenotransplantation nerve bridging. Fecal samples and intestinal contents were collected at three time points: before surgery (Pre group; n = 10), 1

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10404661 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature