Ontology highlight
ABSTRACT:
SUBMITTER: Jiang J
PROVIDER: S-EPMC10404729 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Jiang Jiang J Li Wei W Zhou Lu L Liu Dengping D Wang Yuanyuan Y An Jianzhong J Qiao Shigang S Xie Zhanli Z
iScience 20230719 8
Platelets play an important role in the pathogenesis of sepsis and platelet transfusion is a therapeutic option for sepsis patients, although the exact mechanisms have not been elucidated so far. ITGA2B encodes the αIIb protein in platelets, and its upregulation in sepsis is associated with increased mortality rate. Here, we generated a <i>Itga2b</i> (Q887X) knockin mouse, which significantly reduced ITGA2B expression of platelet and megakaryocyte. The decrease of ITGA2B level aggravated the dea ...[more]