Insulin-like growth factor 1 predicts decompensation and long-term prognosis in patients with compensated cirrhosis.

ABSTRACT:

Aim

Insulin-like growth factor 1 (IGF-1), which is primarily produced in hepatocytes and is associated with liver functional reserve, plays a crucial role in the pathological condition of cirrhosis. This study aimed to investigate the usefulness of serum IGF-1 levels for predicting the long-term prognosis and decompensation development in patients with cirrhosis.

Methods

We retrospectively evaluated 148 patients with cirrhosis and divided them into three groups according to baseline IGF-1 levels: low (L)-, intermediate (I)-, and high (H)-IGF-1 groups. The cumulative survival rates were compared among these groups in compensated and decompensated cirrhosis, respectively. Significant and independent factors associated with mortality and decompensation development were identifi

SUBMITTER: Saeki C 

PROVIDER: S-EPMC10405075 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature