DNA methylation mediated genetic risk in severe acne in a young men population.

ABSTRACT:

Background

Acne is a chronic inflammatory skin disease that affects the pilosebaceous follicle and is influenced by heredity, hormones, inflammation, and the environment. At present, the recognized pathogenesis mainly includes four categories: excessive sebum secretion, excessive Cutibacterium acnes proliferation, excessive keratinization of sebaceous glands in hair follicles, and inflammatory mechanisms. Previous studies have found that DNA methylation is closely related to some chronic inflammatory skin diseases, and there is evidence that DNA methylation is controlled by genetic factors, making us want to know the relationship between DNA methylation, genetic variation and acne.

Materials and methods

In our previous study, we performed genome-wide DNA methylation a

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10405078 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature