Association of DNA methylation signatures with cognitive performance among smokers and ex-smokers.

ABSTRACT:

Introduction

Alterations in DNA methylation profiles have been associated with cancer, and can be influenced by environmental factors such as smoking. A small but growing literature indicates there are reproducible and robust differences in methylation levels among smokers, never smokers, and ex-smokers. Here, we compared differences in salivary DNA methylation levels among current and ex-smokers (at least 2 years abstinent).

Methods

Smokers (n=26) and ex-smokers (n=30) provided detailed smoking histories, completed the Paced Auditory Serial Addition Test (PASAT), and submitted a saliva sample. Whole-genome DNA methylation from saliva was performed, and ANCOVA models and a receiver operating characteristic (ROC) curve were used for the differences between groups and the perf

SUBMITTER: Hsu PC 

PROVIDER: S-EPMC10405227 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature