Clonal haematopoiesis and risk of chronic liver disease.

ABSTRACT: Chronic liver disease is a major public health burden worldwide¹. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis². Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 independent cohorts with whole-exome sequencing data (Framingham Heart Study, Atherosclerosis Risk in Communities Study, UK Biobank and Mass General Brigham Biobank). CHIP was associated with an increased risk of prevalent and incident chronic liver disease (odds ratio = 2.01, 95% confidence interval (95% CI) [1.46, 2.79]; P < 0.001). Individuals with CHIP were more likely to demo

SUBMITTER: Wong WJ 

PROVIDER: S-EPMC10405350 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature