Causal relationships between delirium and Alzheimer's disease: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have reported that delirium has an association with an increased risk of Alzheimer's disease (AD), and that patients with AD have a higher risk of developing delirium. However, due to the limitations of observational study, it is challenging to confirm whether delirium has a causal effect on AD or reverse causation exists.

Methods

A bidirectional two-sample Mendelian randomization (MR) was performed to investigate the relationship between delirium and AD. Summary statistics from genome-wide association studies of delirium and AD phenotypes were utilized. Inverse-variance weighted (IVW) method was used as the main analysis approach, and additional analyses were performed using MR Egger, weighted median, simple mode and weighted mode t

SUBMITTER: Zheng J 

PROVIDER: S-EPMC10405368 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature