Long-term exposure to ambient fine particulate components and leukocyte epigenome-wide DNA Methylation in older men: the Normative Aging Study.

ABSTRACT:

Background

Epigenome-wide association studies of ambient fine particulate matter (PM_2.5) have been reported. However, few have examined PM_2.5 components (PMCs) and sources or included repeated measures. The lack of high-resolution exposure measurements is the key limitation. We hypothesized that significant changes in DNA methylation might vary by PMCs and the sources.

Methods

We predicted the annual average of 14 PMCs using novel high-resolution exposure models across the contiguous U.S., between 2000-2018. The resolution was 50 m × 50 m in the Greater Boston Area. We also identified PM_2.5 sources using positive matrix factorization. We repeatedly collected blood samples and measured leukocyte DNAm with the Illumina HumanMethylation450K Bead

SUBMITTER: Wang C 

PROVIDER: S-EPMC10405403 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature