Effects of remote ischemic conditioning on conditioned pain modulation and cardiac autonomic modulation in women with knee osteoarthritis: placebo-controlled randomized clinical trial protocol.

ABSTRACT:

Background

It is estimated that over 240 million people worldwide have osteoarthritis, which is a major contributor to chronic pain and central changes in pain processing, including endogenous pain modulation. The autonomic nervous system plays a crucial role in the pain regulatory process. One of the main mechanisms of remote ischemic conditioning is neuronal signaling from the preconditioned extremity to the heart. This study aims to analyze the acute effect of remote ischemic conditioning on local pain, conditioned pain modulation, and cardiac autonomic control in women with knee osteoarthritis and to see if there is a correlation between them.

Methods

Women more than 50 years with knee osteoarthritis diagnosed according to the American College of Rheumatology criteria in

SUBMITTER: Biral TM 

PROVIDER: S-EPMC10405415 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature