Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases.

ABSTRACT: The AAA⁺ ATPase valosin containing protein (VCP) is essential for cell and organ homeostasis, especially in cells of the nervous system. As part of a large network, VCP collaborates with many cofactors to ensure proteostasis under normal, stress, and disease conditions. A large number of mutations have revealed the importance of VCP for human health. In particular, VCP facilitates the dismantling of protein aggregates and the removal of dysfunctional organelles. These are critical events to prevent malfunction of the brain and other parts of the nervous system. In line with this idea, VCP mutants are linked to the onset and progression of neurodegeneration and other diseases. The intricate molecular mechanisms that connect VCP mutations to distinct brain pathologies continue to

SUBMITTER: Chu S 

PROVIDER: S-EPMC10405438 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature