The efficacy and safety of vonoprazan-amoxicillin dual therapy in eradicating Helicobacter pylori: a systematic review and meta-analysis.

ABSTRACT:

Aim

To evaluate the efficacy and safety of vonoprazan-amoxicillin (VA) dual therapy for radically eradicating Helicobacter pylori (H. pylori).

Methods

The PubMed, Cochrane Library, Embase, China National Knowledge  Infrastructure (CNKI) and Wanfang databases were searched up to July 7, 2022, to identify clinical trials comparing the efficacy of VA dual therapy and triple therapy for H. pylori eradication. After evaluating the quality of the included studies, random effects models were conducted, and risk ratios (RRs) with 95% confidence intervals (CIs) were calculated to estimate the efficacy and safety of each approach.

Results

Six publications (including four randomized controlled trials) involving 2019 patients were included in this meta-analysis. Overall, the erad

SUBMITTER: Feng JH 

PROVIDER: S-EPMC10405488 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature