3D organization of regulatory elements for transcriptional regulation in Arabidopsis.

ABSTRACT:

Background

Although spatial organization of compartments and topologically associating domains at large scale is relatively well studied, the spatial organization of regulatory elements at fine scale is poorly understood in plants.

Results

Here we perform high-resolution chromatin interaction analysis using paired-end tag sequencing approach. We map chromatin interactions tethered with RNA polymerase II and associated with heterochromatic, transcriptionally active, and Polycomb-repressive histone modifications in Arabidopsis. Analysis of the regulatory repertoire shows that distal active cis-regulatory elements are linked to their target genes through long-range chromatin interactions with increased expression of the target genes, while poised cis-regulatory elements are lin

SUBMITTER: Deng L 

PROVIDER: S-EPMC10405511 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature