Clinical diagnoses associated with a positive antinuclear antibody test in patients with and without autoimmune disease.

ABSTRACT:

Background

Antinuclear antibodies (ANA) are antibodies present in several autoimmune disorders. However, a large proportion of the general population (20%) also have a positive test; very few of these individuals will develop an autoimmune disease, and the clinical impact of a positive ANA in them is not known. Thus, we test the hypothesis that ANA + test reflects a state of immune dysregulation that alters risk for some clinical disorders in individuals without an autoimmune disease.

Methods

We performed high throughput association analyses in a case-control study using real world data from the de-identified electronic health record (EHR) system from Vanderbilt University Medical Center. The study population included individuals with an ANA titer ≥ 1:80 at any time (ANA +)

SUBMITTER: Zanussi JT 

PROVIDER: S-EPMC10405518 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature